Comment Ruby


Respond  to your  colleagues by comparing the differential diagnostic features of the  disorder you were assigned to the diagnostic features of the disorder  your colleagues were assigned.   

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NOTE: Positive comment (bellow is attached the sleep disorder assigned to me)

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Substance /Medication Induced Sexual Dysfunction (SMISD)

            The purpose of this discussion is to  explain the diagnostic criteria for SMISD, and evidence-based  psychotherapy and psychopharmacological

treatment for SMISD. I will be supporting these  treatments and diagnostic criteria with learning course resources and  other academic resources. The

diagnosis of SMISD is when there is evidence of  substance intoxication or withdrawal that is apparent from the history  physical examination or laboratory

results. The sexual dysfunction SMISD occurs soon  after significant substance intoxication or withdrawal, or after  exposure to a medication or a change in

medication use. Some examples of substances and  medications that cause SMISD are alcohol amphetamines or related  substances, cocaine, opioids,

sedatives-hypnotics, anxiolytics, and other known or  unknown substances (Sadock et al., 2014). Almost every pharmacological  agent, especially those in the

psychiatry field have been associated with an effect  on sexuality. In men these effects include low sex drive, erectile  failure, low volume of ejaculate, and

delayed or retrograde ejaculation. In women there is  decreased sex drive, decreased vaginal lubrication, inhibited, or  delayed orgasm and decreased or

absent vaginal contractions may occur. Drugs may also  enhance the sexual responses and increase the sex drive, but this is  less common than adverse

effects (Sadock et al., 2014).

Diagnostic criteria 

            The diagnostic criteria for SMISD requires  that a significant disturbance in sexual function is predominant in the  clinical picture. There SMISD must be

evident from the history, physical examination, or  laboratory findings of a significant sexual dysfunction during or soon  after substance intoxication or

withdrawal or after exposure to her medication. The  involved medication can produce sexual dysfunction symptoms. In  addition, the dysfunction must not

be a result of another dysfunction that is not drug-  induced must not occur during delirium and must cause clinically  significant distress in the client

(Association, 2015).

Psychopharmacology and Psychotherapy for SMISD 

            SMISD can be treated by pharmacologic or  psychotherapy or both. Some classes of medication that can cause sexual  dysfunction antipsychotics. The

prevalence of low libido and problems with orgasm in  patients treated with antipsychotics regardless of sex is 54.2% and  41.7% respectively. A widely

accepted mechanism underlying antipsychotic associated  sexual dysfunction is dopamine D2 receptor antagonism. This causes high  prolactin levels, which

can subsequently lead to a variety of sexual problems  including erectile dysfunction, ejaculatory disturbances and  gynecomastia in men, amenorrhea, and

vaginal dryness in woman. Also, low libido,  anorgasmia, and galactorrhea in both sexes. Some other medications that  cause sexual dysfunction are

antipsychotics, antiparkinsonian drugs,  anticholinergics, antiepileptics, muscle relaxants, cannabis, opioids  and anti-anxiety drugs (Downing et al., 2019).

Psychopharmacological treatments: 

  1. Dose reduction or abstinence  
  2. Switching to a prolactin sparing antipsychotic example Aripiprazole, Olanzapine and Quetiapine 
  3. Augmenting with Aripiprazole. 
  4. Adding Phosphodiesterase inhibitors specifically to treat Ed, PDE-5 inhibitors like Sildenafil can be used. 
  5.  Androgen therapy for male and female. 
  6. Bupropion and some second-generation antipsychotics. 
  7. Testosterone replacement and low  hepatic impact medications, H1 receptor antagonism with allergic  antihistamine use improves ED. 
  8. Alprostadil and injectable medications Edex, MUSE and Brevital. 
  9. Anti-depressants can be used for treating phobic sex
  10. Trazodone can be used to increase nocturnal erections (Razdan et al., 2017). 


  1. Dual-sex therapy 
  2. Hypnotherapy 
  3. Behavior therapy 
  4.  Mindfulness in cognitive technique 
  5. Group therapy 
  6. Specific techniques and exercises 
  7. Analytically oriented sex therapy (Sadock et al., 2014) 


            Clinicians need to be more vigilant about  antipsychotic- associated sexual dysfunction and available treatment  options, because these adverse effects

can affect a patient’s quality of life and adherence  to anti-psychotic medication (Downing et al., 2019). Maintaining good  sexual health and function is

especially important in these patients to help improve  their mood, quality of life and medication compliance. The specific  aspect of sexual function that is

affected by psychiatric drugs is often ambiguous when  described in current literature. Broad questionnaires like the Arizona  Sexual Experience Scale can be

used to evaluate many components of sexual health (Razdan et al., 2017).


            Association, A. P. (2015). Dsm-5® (5th ed.). American Psychiatric Association.

            Downing, L., Kim, D. D., Procyshyn, R. M., & Tibbo, P. (2019). Management of sexual adverse

                          effects induced by atypical antipsychotic medication. Journal of Psychiatry and 

                          Neuroscience, 44(4), 287–288.

           Razdan, S., Greer, A. B., Patel, A., Alameddine, M., Jue, J. S., & Ramasamy, R. (2017). Effect

                          of prescription medications on erectile dysfunction. Postgraduate Medical Journal,

                         94(1109), 171–178.

            Sadock, B. J., Sadock, V. A., & Pedro, R. M. (2014). Kaplan and sadock’s synopsis of 

                          psychiatry: Behavioral sciences/clinical psychiatry (11th ed.). Lww.

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